Hydroxychloroquine-induced hyperpigmentation the staining pattern


Risk factors appear to be linked to bruising, corticosteroid use, oral anticoagulants, antiplatelet agents, antiphospholipid syndrome and skin trauma.1 Histology usually shows superficial dermal depo-sition of …. Antimalarial drug–induced oral hyperpigmentation is uncommon and is reported to occur on the hard palate, gingiva, lips, and buccal mucosa.15, 47 In a retrospective study, pigmentation of the buccal mucosa or the hard palate was seen in 10 patients (5%) using chloroquine, but none in hydroxychloroquine, 50 and there are rare case reports of. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. Incidence ranges from 3-20% (2-4). Within the eye, hydroxychloroquine can adversely impact the cornea, ciliary body, and retina[1]. Other cutaneous lesions including lichenoid lesions and a nonspecific inflammation associated with or without photosensitivity may occasionally accompany hyperpigmentation. The woman stopped hydroxychloroquine therapy; 10 months later, a partial regression of the hyperpigmentation was noted Oct 18, 2011 · Hydroxychloroquine and chloroquine are both 4-amino-quinolines; hydroxychloroquine is an analog of chloroquine formed by β-hydroxylation of …. Urowitz and Paul R. To our knowledge, this staining pattern for hydroxychloroquine has not been previously reported in the literature and supports that hydroxychloroquine, in addition to chloroquine, binds to melanin We report two cases of hydroxychloroquine-induced hyperpigmentation presenting in a 50-year-old Caucasian female (case 1) and a 78-year-old female (case 2), both receiving 400 mg per day. J Cutan Pathol 2008; 35: 1134–1137. Patients and methods A 67-year-old male was treated with meropenem (1 g × 4 daily), levofloxacin (500 mg twice daily) and amikacin (500 mg daily) for 2 weeks, followed by meropenem, levofloxacin and hydroxychloroquine-induced hyperpigmentation the staining pattern rifampicin (600 mg twice daily) for 4 weeks for osteitis of the fifth metatarsal Jun 17, 2003 · HCQ also induces mitochondrial membrane permeabilization (MMP), as indicated by the insertion of Bax into mitochondrial membranes, the conformational activation of Bax within mitochondria, the release of cytochrome c from mitochondria, and the loss of …. Side effects are usually mild and may include nausea and diarrhea. 4 Puri PK, Lountzis NI, Tyler W, Ferringer T. Apr 11, 2019 · Hydroxychloroquine induced cutaneous pigmentation: a unique pattern (6 February, 2019) Vishal Thakur, Amit Dalla, Sheetanshu Kumar, Muthu Sendhil Kumaran, Divya Aggarwal, Bishan Dass Radotra. Apr 11, 2019 · Hydroxychloroquine induced cutaneous pigmentation: a unique pattern (6 February, 2019) Vishal Thakur , Amit Dalla , Sheetanshu Kumar , Muthu Sendhil Kumaran , Divya Aggarwal , …. Remarkably, silencing AK2 exerted the greater tumor suppression roles hydroxychloroquine-induced hyperpigmentation the staining pattern when combined with hydroxychloroquine, an effective autophagy inhibitor, in vitro and in xenografts mouse models Mar 27, 2020 · Lentinula edodes is one of the most popular edible mushrooms worldwide and contains important medicinal components such as lentinan, ergosterol, and eritadenine. Two cases of cutaneous hyperpigmentation have been reported following use of levofloxacin, and the results of histological examination were similar. Visitas Hydroxychloroquine-induced hyperpigmentation: The staining pattern. Sawalha Hydroxychloroquine-Induced Pigmentation in Patients With https://jamanetwork.com/journals/jamadermatology/fullarticle/1708456 Aug 01, 2013 · Objective To describe the clinical features and outcome of hydroxychloroquine (HCQ)-induced pigmentation in patients with systemic lupus erythematosus (SLE). Type I, the most common, is ….

Is Chloroquine Safe In G6pd Deficiency


We report a case of cutaneous hyperpigmentation induced by meropenem and levofloxacin. Its main side effects are gastrointestinal upset, skin rash, headache, and ocular toxicity[1]. An. Given that Hydroxychloroquine (HCQ), a widely-used CLE therapy, and 24F4A are both able to inhibit pDC-derived IFN-I production; this study aimed to determine whether 24F4A would show an additional inhibitory effect on pDC response after ex vivo or in vivo treatment with HCQ Right ventricular biopsy was negative on Congo red staining. The pigmentation patterns were variable within and between patients. Apr 30, 2018 · Drug-induced skin disorders may manifest in a variety of ways. Chloroquine and hydroxychloroquine, commonly used for rheumatologic conditions, are rare yet very important causes of toxic myopathy with vacuolar changes on muscle biopsy. Medical history was notable for rheumatoid arthritis, hypertension, and hyperlipidemia.. To our knowledge, this staining pattern for hydroxychloroquine has not been previously reported in the literature and supports that hydroxychloroquine, in addition to chloroquine, binds to melanin. Discussion Oral mucosal pigmentation can be result of a wide va-riety of lesions and conditions. OBSERVATIONS: We describe the occurrence of cutaneous hyperpigmentation after photosensitivity in 2 patients who were treated with vandetanib. 1,2 It has been estimated that up to 10% of systemic lupus erythematosus (SLE) cases are drug induced, which approximates to 15,000 to 30,000 cases per year. Puri, Nektarios I. J Cutan Pathol, 35 (2008), pp. Pigmentation may be induced by a wide variety of drugs; the main ones implicated include non-steroidal anti- inflammatory drugs ( NSAIDs ), phenytoin, antimalarials , amiodarone, antipsychotic drugs, cytotoxic drugs , tetracyclines , and heavy metals Antimalarial drug–induced oral hyperpigmentation is uncommon and is reported to occur on the hard palate, gingiva, lips, and buccal mucosa.15, 47 In a retrospective study, pigmentation of the buccal mucosa or the hard palate was seen in 10 patients (5%) using chloroquine, but none in hydroxychloroquine, 50 and there are rare case reports of. Chloroquine (CQ) and hydroxychloroquine (Plaquenil) (HCQ) have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis hydroxychloroquine-induced hyperpigmentation the staining pattern and lupus [1]. Chloroquine was first used as an antimalaria drug. Implicated agents include alkylating/cytotoxic agents, analgesics, antiarrhythmics, anticoagulants, antiepileptics, antimalarials, antimicrobials, antiretrovirals, …. It’s one of the best tolerated DMARDs. Introduction. In addition, the pattern of pigmentation may provide clues to. JAMA Dermatol 2013; 149: 935–940 hydroxychloroquine; pigmentation; An elderly woman presented with 6 months history of skin coloured to erythematous papules in annular pattern over extremities, upper back and neck. Pigment granules may be of both melanin and hemosiderin, or of hemosiderin or melanin alone (6). This is the first case of …. Hydroxychloroquine is most frequently used for the management of lupus and rheumatoid arthritis; however, it is now being applied to treatments in adjunctive cancer therapy,. Hydroxychloroquine-induced pigmentation in patients with systemic lupus erythematosus: A case-control study. In our case, infrared spectroscopy enabled us to identify meropenem in the dermis. To our knowledge, this staining pattern for hydroxychloroquine has not been previously reported in the literature and supports that hydroxychloroquine, in addition to chloroquine, binds to melanin. However, little is known about its role in renal ischemia. Pooneh S. JAMA Dermatol 2013; 149: 935–940 Hydroxychloroquine is an antimalarial medication that can cause hyperpigmentation of nails, mucosa, and hydroxychloroquine-induced hyperpigmentation the staining pattern skin [1–5]. Generalized skin hyperpigmentation and longitudinal melanonychia secondary to treatment with hydroxychloroquine in systemic lupus erythematosus. Hydroxychloroquine is most frequently used hydroxychloroquine-induced hyperpigmentation the staining pattern for the management of lupus and rheumatoid arthritis; however, it is now being applied to treatments in adjunctive cancer therapy,. Topical corticosteroids induced hyper-pigmentation: a case report Hyper-pigmentation is a common skin condition in which increased melanin production results in darker patches of skin.

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